Professor, Doctoral supervisor
Research Areas
Modern pharmaceutical analysis
Surface-enhanced Raman scattering (SERS) spectroscopy
Molecular imprinting technique
Optical Nanoprobes for Cancer Detection and Imaging
Education & Positions
1987-2004 Anhui Academy of Medicical Sciences, Research assistant, Associate researcher, Researcher
2004-
Faculty Accolades
Jiangsu Provincial 6th Session Talent Summit, 2008
Jiangsu Chinese medicine science and Technology Award, 2017
Grants and fundings
The National 863 High Technology Project of
The National Natural Science Foundation of
The Doctoral Program of Higher Education of China (no.20113234110001)
The Program of
Publications
[.. 1] Junhui by by You, Zhengyi,, by by You, Xin Xu, Jiangrong Ji, Tian Lu, Yuhong Xia, of of Lipin Wang, Liying Zhang, Shuhu Du *. A Split aptamers-Labeled ratiometric Fluorescent Biosensor for specific Detection of adenosine in Human urine. Microchimica Sinensis , 2019 , 186 (1): 43. https://doi.org/10.1007/s00604-018-3162-2.
[2] Qiang Da, Yuanyuan Gu, Xiafeng Peng, Liying Zhang*, Shuhu Du *. Colorimetric and visual detection of mercury(II) based on the suppression and interaction of dithiothreitol with agar-stabilized silver-coated gold nanoparticles. Microchimica Acta , 2018 , 185: 357-365.
[3] Chunchen Zheng , Liying Zhang , Fangyuan Wang, Shanqing Cai, Shuhu Du *, Zhongping Zhang. Silver nanoparticles/activated carbon composite as a facile SERS substrate for highly sensitive detection of endogenous formaldehyde in human urine by catalytic reaction.Talanta , 2018 , 188 : 630–636
[2] Xiaoling Gu, #, Yang Jin, #, Fang Dong, of Yueqing Cai, Zhengyi by You, Junhui by You, Liying Zhang, Shuhu Du *. Toward Rapid the Analysis, Forecast and Discovery of BioActive Compounds from Herbs by Jointly a using Thin Layer Chromatography And ratio metric surface-enhanced Raman spectroscopy technique. Journal of Pharmaceutical and Biomedical Analysis , 2018 , 153 : 9–15
[. 3] of Yueqing Cai, Junhui by You, Zhengyi, by You, Fang Dong, Shuhu Du * , Liying Zhang * . Profuse Evolution-Color Fluorescent Test Paper-based Sensor for Monitoring of Rapid Visual endogenous and a Cu 2+ in Human urine. Biosensors and Bioelectronics , 2018 , 99 : 332 – 337
[4] Fangyuan Wang, Xiaoling Gu, Chunchen Zheng, Fang Dong, Liying Zhang, Yueqing Cai, Zhengyi You, Junhui You, Shuhu Du *, and Zhongping Zhang. Ehrlich reaction evoked multiple spectral resonances and gold nanoparticle hotspots for Raman detection of plant Horm. Analytical Chemistry , 2017 , 89 (17) : 8836–8843
[5]Yang Jin † , Junting Fan † , Xiaoling Gu, Liying Zhang, Jing Han, Shuhu Du *, and Aixia Zhang*. Neuroprotective activity of cerebrosides from Typhonium giganteum by regulating caspase-3 and Bax/Bcl-2 signaling pathways in PC12 cells. Journal of Natural Products , 2017 , 80 (6) : 1734–1741
[6] Qing Zhang ∗ , Haoyu Zhao, Dong Li, Liping Liu, Shuhu Du ∗ .A surface-grafted ligand functionalization strategy for coordinate binding of doxorubicin at surface of PEGylated mesoporous silica nanoparticles: Toward pH-responsive drug delivery. Colloids and Surfaces B: Bio interfaces , 2017 , 149 : 138–145
[7] Xiaoyan Huang † , Yujie Zhou † , Cui Liu , Ruilong Zhang , Liying Zhang , Shuhu Du *, Bianhua Liu , Ming-Yong Han , Zhongping Zhang *. A single dual-emissive Nano fluorophore test paper for highly sensitive colorimetric-based quantification of blood glucose. Biosensors and Bioelectronics , 2016 , 86 : 530 – 535
[8] Yujie Zhou † , Xiaoyan Huang † , Cui Liu, Ruilong Zhang, Xiaoling Gu, Guijian Guan, Changlong Jiang, Liying Zhang, Shuhu Du * , Bianhua Liu, Ming-Yong Han, Zhongping Zhang * . Color-Multiplexing-based Fluorescent test paper: dosage-sensitive visualization of arsenic(III) with discernable scale as low as 5 ppb. Analytical Chemistry , 2016 , 88 (12) : 6105–6109
[9] Liying Zhang†, Yang Jin†, Xiaoyan Huang, Yujie Zhou, Shuhu Du , * Zhongping Zhang. Ligand replacement approach to Raman-responded molecularly imprinted monolayer for rapid determination of penicilloic acid in penicillin. Analytical Chemistry , 2015, 87 ( 23) : 11763–11770
[10] Meihui Qi, Xiaoyan Huang, Yujie Zhou, Liying Zhang, Yang Jin, Yan Peng, Huijun Jiang, Shuhu Du *. Of The the Label-as Free Surface-Enhanced RAMAN and Scattering Strategy for Rapid Detection of penicilloic acid in Milk Products's. Food Chemistry , 2016 , 197 (Part A): 723–729
[11] Hui Mao, Mei Hui Qi, Yu Jie Zhou, Xiao Yan Huang, Li Ying Zhang, Yang Jin, Yan Peng, Shuhu Du *. Discrimination of sibutramine and its analogues based on surface-enhanced Raman spectroscopy and chemo metrics: toward rapid detection of synthetic Anorexic Drug in natural slimming product. RSC Advances , 2015 , 5(8): 5886–5894
[12] Guangmei Han, Renyong Liu, Ming-Yong Han, Changlong Jiang, Jianping Wang, Shuhu Du , Bianhua Liu, * and Zhongping Zhang. Label-Free Surface-Enhanced Raman Scattering Imaging to Monitor the Metabolism of Antitumor Drug 6 ‐ Mercaptopurine In Living Cells. Analytical Chemistry , 2014 , 86 (23): 11503–11507
[13] Peng Wang†, Aixia Zhang†, Yang Jin, Qing Zhang, Li Ying Zhang, Yan Peng , Shuhu Du *. Molecularly imprinted layer-coated hollow polysaccharide microcapsules toward gate controlled release of water-soluble drugs. RSC Advances , 2014 , 4 (50): 26063-26073
[14] Lei Zheng, Hui Mao, Li Ying Zhang, Yang Jin, Yu Jie Zhou, Yan Peng, Shuhu Du *. Aminopyrine Raman spectral features characterized by experimental and theoretical methods: Toward rapid SERS detection of synthetic antipyretic-analgesic drug in traditional Chinese medicine . Analytical Methods , 2014 ,6(15): 5925–5933
[15] Qing Zhang, Liying Zhang,Peng Wang , Shuhu Du * .Coordinate bonding strategy for molecularly imprinted hydrogels: Toward pH-responsive doxorubicin delivery. Journal of Pharmaceutical Sciences , 2014 , 103(2):643-651
[16] Liying Zhang, Yang Jin, Hui Mao, Lei Zheng, Jiawei Zhao, Yan Peng, Shuhu Du *, Zhongping Zhang* . Structure-selective hot-spot Raman enhancement for direct identification and detection of trace penicilloic acid allergen in penicillin. Biosensors and Bioelectronics , 2014 , 58:165 – 171
[17] Jiawei Zhao † , Li Nie † , Liying Zhang , Yang Jin , Yan Peng , Shuhu Du * ,
[18] Jing Luo , Liying Zhang , Chen Danjun, Peng Wang, Jia w ei Zhao, Yan Peng, Shuhu Du * , Zhongping Zhang * .Molecularly imprinted layer-coated monodisperse spherical silica micro particles toward affinity-enrichment of isoflavonoid glycosides from Radix Puerariae.Analyst , 2012 , 137 (12):2891 - 2902
[19] Danjun Chen, Junting Fan , Peng Wang , Lanying Zhu, Yang Jin, Yan Peng , Shuhu Du *. Isolation, identification and antioxidative capacity of water-soluble phenylpropanoid compounds from Rhodiola crenulata. Food Chemistry , 2012 ,134 (4) : 2126-2133
[20] Ying Xie, Dan Jun Chen, Jia Wei Zhao , Yan Peng , Nan Jiang , Xuemin Zhou , Shuhu Du * , Zhongping Zhang * .An efficient hybrid design to prepare highly dense imprinted layer-coated silica particles for selective uptake of trace metsulfuron-methyl from complicated matrices. RSC Advances , 2012 ,2(1) : 273 - 283
[21 is] Shu Wang, Yun of Li, Meijuan Ding, Xiaoli Wu, of Jinhui Xu, Ruoyu Wang, while Tingting Wen, Wenyu Huang, the Ping Zhou, Kunfang Ma, Xuemin Zhou * , Shuhu Du * . Self-Assembly Molecularly Imprinted Polymers of. 17 beta] -estradiol on the surface of magnetic nanoparticles for selective separation and detection of estrogenic hormones in feeds. Journal of Chromatography B , 2011 ,879 (25): 2595 - 2600
[22] Qing Lu, Xue Mei Chen, Li Nie, Jing Luo, Huijun Jiang, Lina Chen, Qin Hu, Shuhu Du * , Zhongping Zhang. Tuning of the vinyl groups' spacing at surface of modified silica in preparation of high density imprinted Layer -dispersive silica nanoparticles: A dispersive solid-phase extraction material for chlorpyrifos.Talanta , 2010 , 81(3) : 959 – 966
[23] Yan Peng, Ying XieJing Luo, Li Nie,Yun Chen, Lina Chen, Shuhu Du* , Zhongping Zhang * . Molecularly imprinted polymer layer-coated silica nanoparticles toward dispersive solid-phase extraction of trace sulfonylurea herbicides from soil and crop samples. Analytical Chimica Acta, 2010 , 674(2) : 190
– 200
[24] Chun Xiao Zhai, Qing Lu, Xue Mei Chen, Yan Peng, Lina Chen, Shuhu Du *. Molecularly imprinted layer-coated silica nanoparticles toward highly selective separation of active diosgenin from Dioscorea nipponica Makino. Journal of Chromatography A , 2009 , 1216 (12) : 2254 – 2262
[25] Yan Peng, Jing Luo, Qing Lu, Xue Mei Chen, Ying Xie, Lina Chen, Wei Yang, Shuhu Du *. HPLC analysis, semi-preparative HPLC preparation and identification of three impurities in salidroside bulk drug. Journal of Pharmaceutical And Biomedical Analysis , 2009 , 49(3) : 828 – 832
