Zhu Ya-dong, PhD, Professor, Department of Pharmacology, School of Pharmacy, Director of the Cell and Stem Institute of Neuro-Regeneration, Nanjing Medical University Research, Focus ON :. Interests (. 1) The treatment of New Targets for new New Stroke and Drugs OTHER for Stroke and for cerebrovascular s diseases ; (2) New Targets for treatment of Emotional Disorders The new new Drugs Discovery and for anxiety and Depression Disorder .
Representative publications
1. Liu MY , CY Yin, Zhu LJ, Zhu XH, Xu C, the CX Luo, Chen H, Zhu DY, Zhou QG Sucrose by the preference Test for Measurement of Stress-induced anhedonia in MICE. Nat Protoc 2018; 13 is :. 1686 -1698.
2. Zhang Y, Zhu Z, Liang HY, Zhang L, Zhou QG, Ni HY, Luo CX, Zhu DY . nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages. Aging Cell .2018:e12754 .
3. Lin YH, Liang HY, Xu K, Ni HY, Dong J, Xiao H, Chang L, Wu HY, Li F, Zhu DY , Luo CX. Dissociation of nNOS from PSD-95 promotes functional recovery after cerebral ischaemia in mice Through reducing excessive tonic GABA release from reactive astrocytes. J Pathol. 2018; 244: 176-188.
4. Tang Y, Lin YH, Ni HY, Dong J, Yuan HJ, Zhang Y, Liang HY, Yao MC, Zhou QG, Wu HY, Chang L, Luo CX, Zhu DY . Inhibiting Histone Deacetylase 2 (HDAC2) Promotes Functional Recovery From Stroke. J Am Heart Assoc .2017;6: e007236
5. Lin YH, Dong J, Tang Y, Ni HY, Zhang Y, Su P, Liang HY, Yao MC, Yuan HJ, Wang DL, Chang L, Wu HY, Luo CX, Zhu DY . Opening a New Time Window for Treatment of Stroke by Targeting HDAC2. J Neurosci 2017;37:6712-6728.
6. Zhou QG, Liu MY, Lee HW, Ishikawa F, Devkota S, Shen XR, Jin X, Wu HY, Liu Z, Liu X, Jin X, Zhou HH, Ro EJ, Zhang J, Zhang Y, Lin YH, Suh H, Zhu DY . Hippocampal TERT regulates spatial memory formation through modulation of neural development. Stem Cell Rep .2017;9:543-556
7. Zhou HH, Tang Y, Zhang XY, Luo CX, Gao LY, Wu HY, Chang L, Zhu DY .Delayed Administration of Tat-HA-NR2B
8. Luo CX, Lin YH, Qian XD, Tang Y, Zhou HH, Jin X, Ni HY, Zhang FY, Qin C, Li F, Zhang Y, Wu HY, Chang L, Zhu DY . Interaction of nNOS with PSD- 95 Negatively Controls Regenerative Repair after Stroke. J Neurosci .2014, 34:13535-13548.
9. Zhu LJ, Li TY, Luo CX, Jiang N, Chang L, Lin YH, Zhou HH, Chen C, Zhang Y, Lu W, Gao LY, Ma Y, Zhou QG, Hu Q, Hu XL, Zhang J, Wu HY, Zhu DY .CAPON-nNOS coupling can serve as a target for developing new anxiolytics. Nat Med .2014, 20: 1050-1054.
10. Hu Y, Wu DL, Luo CX, Zhu LJ, Zhang J, Wu HY, Zhu DY . Hippocampal nitric oxide contributes to sex difference in affective behaviors. Proc Natl Acad Sci USA .2012, 109: 14224-14229.
Zhou QG 11. The, Zhu LJ, Chen C, HY Wu, Luo the CX, Chang L, Zhu DY. Hippocampal neuronal nitric oxide synthase Current current mediates depressive of The Stress-Related Behaviors of glucocorticoids by downregulating glucocorticoid receptor. J Neurosci 2011 ; 31 is:. 7579 -7590.
12. Zhou QG, Hu Y, Wu DL, Zhu LJ, Chen C, Jin X, Luo CX, Wu HY, Zhang J, Zhu DY .Hippocampal telomerase is involved in the modulation of depressive behaviors.). J Neurosci 12258- 12269 .
13. Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM, Lu W, Ji X, Zhou QG, Zhu DY. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med .2010;16(12):1439-1443.
14. Luo CX, Jin X,
15. Zhang J, Huang XY, Ye ML, Luo CX, Wu HY, Zhu DY . Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A -receptor in modulating anxiety-related behaviors. J Neurosci 2010;30:2433- 2441.
16. Peng PL, Zhong X, Tu W, Soundarapandian MM, Molner P, Zhu DY , Lau L, Liu S, Liu F, Lu Y. ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determined vulnerability of neurons in forebrain ischemia. Neuron 2006; 49: 719-33.
17. Liu S, Lau L, Wei J, Zhu DY , Zou S, Sun HS, Fu Y, Liu F, Lu Y. Expression of Ca(2+)-permeable AMPA receptor channels primes cell death in transient for ebrain ischemia. Neuron. 2004; 43: 43-55.
18. Zhu DY , Lau L, Liu SH, Wei JS, Lu YM. Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci
19. Zhu DY , Liu SH, Sun HS, Lu YM. Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci 2003; 23:223-229.
