Current Position:-
Professor, PhD Superviser, Vice President of Nanjing Medical University, Director of the Key Laboratory of Cardiovascular & Cerebrovascular Medicine.
Professional Biography:-
Professor Yong Ji was awarded the bachelor degree in Medicine in 1991, and the PhD degree in cardiovascular pharmacology in 1998 from Nanjing Medical University.
Dr. Ji was granted by French Ministry of Science and completed the postdoctoral training in French National Academy of Medical Sciences (INSERM U464) and Marseille Mediterranean University from 2000-2002 . Then Dr Ji was granted by Welcome Trust funding and worked as a research fellow In King's College London in UK from 2002 to 2004 . Dr. Ji joined Nanjing Medical University as the full-time professor since 2004.
Professor Yong Ji Is active in research of cardiovascular pharmacology, focusing on gasotransmitters - nitric oxide and hydrogen sulfide effects on various cardiovascular diseases s , including vascular endothelial dysfunction, myocardial ischemia-reperfusion injury, myocardial hypertrophy, diabetes and atherosclerosis. The research group is currently Focus on S-nitrosylation and S-sulfhdration of proteins by NO and H2S respectively . He has published over 80 research papers in many international prestigous journals, including Circ Res, Nat Commun, Proc Natl Acad Sci USA, Diabetes, Antioxid Redox Signal, Cardiovasc Res, J Mol Cell Cardiol, Br J Pharmacol , and etc.
Research Interests
C ardiovascular the MEDICA .
Awards
Six Talent Peaks Project in Jiangsu Province, 2009.
The Third Level of 333 High-level Talents Training Project, 2013.
Second Prize of Chinese Medical Science and Technology Award, 2014.
First Prize of Famous Achievement Award Of the Science Technology in Higher Institution, 2017.
First Prize of Jiangsu Science and Technology Progress Award, 2017.
National Hundred, Thousand and Ten Thousand Talent Project, 2017.
National Middle-aged and Young Experts with outstanding Contribution, 2017.
The Second Level of 333 High-level Talents Training Project, 2018.
Boards and Committees
Asian Associate Managing Editor of British Journal of Pharmacology.
Vi ce C hairman of A therosclerosis Committee in Chin ese Association of P athophysiology .
C hairman Of the Bioactive Small Molecule Committee of the Chinese Society of Pathophysiology.
Deputy Director of Jiangsu Province Pharmacological Society.
Member of C ardiovascular P harmacology Committee In Chinese Pharmacological Society.
Member of Cardiovascular Committee of Chinese Society of Pathophysiology.
Member of Lipid and Lipoprotein committee in Chinese Association of Biochemistry and Molecular Biology.
Member of British Pharmacological Society.
Member of the China Council of the International Heart Research Association.
Executive Director of the Academic Committee of Cardiovascular Diseases of the China-Russia Medical University Alliance.
Review Expert of Youth Thousand Talents Program of National Natural Science Foundation of China.
Review Expert of Key Program , Major Program and Youth P rogram of National Natural Science Foundation of China .
Fundings
Professor Yong Ji is in charge of multiple research projects, Including the State Key Program of National Natural Science , Key Program of Major Research Plan of National Natural Science , Key International (Regional) Cooperative Research Project of National Natural Science and Major Program of National Natural Science And etc.
National Authorized Invention Patents
Application of hydrogen sulfide and its donors in improving sperm quality and function (No. ZL201310694659.7 ) .
Application of Histidine Triad Nucleotide-binding Protein (No. ZL201711246138.X ) .
Publications (2013-1019)
1. Shan LY , Li JZ , Zu LY , Niu CG , Ferro A , Zhang YD , Zheng LM* , Ji Yong . Platelet-derived microparticles are implicated in remote ischemia conditioning in a rat model of cerebral infarction. CNS Neurosci Ther . 2013 ;19(12):917-25.
2. Gu L , Bai W , Li S , Zhang Y , Han Y , Gu Y, Meng G, Xie L, Wang J, Xiao Y, Shan L, Zhou S, Wei L, Ferro A, Ji Yong. Celastrol prevents atherosclerosis Via inhibiting LOX-1 and oxidative stress. PLoS One . 2013;8(6):e65477.
3. Liu Z , Han Y , Li L , Lu H , Meng G , Li X, Shirhan M, Peh MT, Xie L, Zhou S, Wang X, Chen Q, Dai W, Tan CH, Pan S, Moore PK, Ji Yong . The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice. Br J Pharmacol . 2013;169(8):1795-809.
4. Yu SS , Cai Y , Ye JT, Pi RB, Chen SR, Liu PQ*, Shen XY*, Ji Yong. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitrovia inhibition of NF-κB-dependent transcriptional activity. Br J Pharmacol 2013 ;168(1): 117-28.
5. Zhang W , Han Y , Meng G , Bai W, Xie L, Lu H, Shao Y, Wei L, Pan S, Zhou S, Chen Q, Ferro A*, Ji Y* . Direct renin inhibition with Aliskiren protects against Myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats. J Am Heart Assoc . 2014; 3(1):e000606.
6. Yang J , Wu J, Liu Y, Huang J, Lu Z, Xie L, Sun W*, Ji Yong Porphyromonas gingivalis infection reduces regulatory T cells in infected atherosclerosis patients. PLoS One . 2014;9(1) : E86599 .
7. Meng G , Zhu J , Xiao Y , Huang Z , Zhang Y , Tang X , Xie L , Chen Y , Shao Y , Ferro A , Wang R , Moore PK , Ji Y * . Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis . Oxid Med the Cell longev 2015, 2015: 691.07.
8. Meng G , Wang J , Xiao Y , Bai W , Xie L, Shan L, Moore PK, Ji Y* . GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. J Biomed Res . : 203 -13.
9. Cheng WL , Wang PX, Wang T, Zhang Y, Du C, Li H*, Ji Yong . Regulator of G-protein signalling 5 protects against atherosclerosis in apolipoprotein E-deficient mice. Br J Pharmacol . 2015;172 ( 23 ): 5676-89.
10. Meng G , Ma Y, Xie L, Ferro A, Ji Y* . Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases. Br J Pharmacol . 2015;172(23):5501-11.
11. Chao ML , Guo J, Cheng WL, Zhu XY, She ZG, Huang Z, Ji Y*, Li H*. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc . 2016 ;5(12). pii: e004362.
12. Yang J , Fang P, Yu D, Zhang L, Zhang D, Jiang X, Yang WY, Bottiglieri T, Kunapuli SP, Yu J, Choi ET, Ji Y*, Yang X, Wang H*. Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation. Circ Res 2016;119(11):1226-41.
13. Xie L , Gu Y , Wen M, Zhao S, Wang W, Ma Y, Meng G, Han Y, Wang Y, Liu G, Moore PK, Wang X, Wang H, Zhang Z, Yu Y, Ferro A, Huang Z*, Ji Y* Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation. Diabetes. 2016;65(10):3171-84.
14. Meng G , Xiao Y, Ma Y, Tang X, Xie L, Liu J, Gu Y, Yu Y, Park CM, Xian M, Wang X, Ferro A, Wang R, Moore PK, Zhang Z, Wang H , Han Y*, Ji Y*. Hydrogen Sulfide Regulates Krüppel-Like Factor 5 Transcription Activity via Specificity Protein 1 S-Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy. J Am Heart Assoc. 2016;5(12). pii: e004362.
15. Xi H , Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y*, Yang X, Wang H*. Caspase-1 Inflammasome Activation Mediates Homocysteine -Induced Pyrop- Apoptosis in Endothelial Cells. Circ Res. 2016;118(10):1525-39.
16. Tang Y , Li S , Zhang P , Zhu J , Meng G , Xie L , Yu Y , Ji Y* , Han Y* . Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats. Oxid Med Cell Longev. 2016;2016:5057405 .
17. Gu Y , Tang X, Xie L, Meng G*, Ji Y*. Aliskiren improves endothelium-dependent relaxation of thoracic aorta by activating PI3K/Akt/eNOS signal pathway in SHR. Clin Exp Pharmacol Physiol 2016;43( 4 ) : 450-58.
18. Xie L , Feng H, Li S, Meng G, Liu S, Tang X, Ma Y, Han Y, Xiao Y, Gu Y, Shao Y, Park CM, Xian M, Huang Y, Ferro A, Wang R Moore PK, Wang H *, Ji Y*. SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016;24(6):329-43.
19. Liu W*, Ruiz-Velasco A, Wang S, Khan S, Zi M, Jungmann A, Dolores Camacho-Muñoz M, Guo J, Du G, Xie L, Oceandy D, Nicolaou A, Galli G, Müller OJ, Cartwright EJ, Ji Y*, Wang X*. Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nat Commun. 2017;8(1):494.
20. Chen Y , Meng G, Bai W, Ma Y, Xie L, Altaf N, Qian Y, Han Y*, Ji Y*. Aliskiren protects against myocardial
Ischaemia-reperfusion injury via an endothelial nitric oxide synthase dependent manner. Clin Exp Pharmacol Physiol. ;44(2): 266-74.
21. Chun-Mei J , Wu C, Guo-Liang M, Yue G, Ning C*, Ji Y*. Production of endogenous hydrogen sulfide in human gingival tissue. Arch Oral Biol. 2017;74:108-13.
22. Wang J , Wang W , Li S , Han Y , Zhang P , Meng G , Xiao Y , Xie L , Wang X , Sha J , Chen Q , Moore PK , Wang R , Xiang W* , Ji Y* . Hydrogen Sulfide as a potential target in preventing spermatogenic failure and testicular dysfunction. Antioxid Redox Si gn Al. 2018;28(16):1447-62.
23. Meng G , Liu J, Liu S, Song Q, Liu L, Xie L, Han Y, Ji Y*. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner. Br J Pharmacol 2018; 8) : 1126-45.
24. Meng G , Zhao S, Xie L, Han Y, Ji Y*. Protein S-sulfhydration by hydrogen sulfide in cardiovascular system. Br J Pharm acol. 2018;175(8):1146-56.
25. Lin Z Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasoe activation via S- Sulfhydrating c-Jun at Cys269 in macrophages. Biochim Biophys Acta. 2018; 1864 (9 Pt B): 2890-900.
26. Cueto R , Zhang L, Shan HM, Huang X, Li X, Li YF, Lopez J, Yang WY, Lavallee M, Yu C, Ji Y*, Yang X, Wang H*. Identification of homocysteine-suppressive mitochondrial ETC Complex genes and tissue Expression profile - Novel hypothesis establishment. Redox Biol. 2018;17:70-88.
27. Wang X , Huang Y, Ji Y*. Spotlight on small molecules in cardiovascular diseases. Br J Pharmacol. 2018;175(8):1111-13.
28. Mao Y , Wang L, Zhu Y, Liu Y, Dai H, Zhou J, Geng D*, Wang L*, Ji Y*. Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β / --catenin signaling pathway. J Mol Histol. 2018;49(1):75-84.
29. Wu J , Xing C , Zhang L, Mao H, Chen X, Liang M, Wang F, Ren H, Cui H, Jiang A, Wang Z, Zou M*, Ji Y*. Autophagy promotes fibrosis and apoptosis In Cellat Mol Med. J Cell Mol Med. 2018;22(2):1190-201. In the peritoneum during long-term peritoneal dialysis .
30. A Wang W is , Wang D, C Kong, of Li S, Xie L, Lin the Z, the Y Zheng, Zhou J, Han the Y *, the Y Ji *. S-nitrosylation of eNOS BY OxLDL- Mediated Endothelial dysfunction induced Via Increasing The Interaction of eNOS with β-catenin. Biochim Biophys Acta. 2018 Feb 20. pii: S0925-4439(18)30066-8
