Zhong Caiyun
1. Personal Information
Title/Position: Director and Professor of Nutrition and Food Hygiene
Correspondence Address: Department of Social Medicine and Health Education, Nanjing Medical University, 101 Longmian Av., Jiangning District, Nanjing, Jiangsu Province, 211166, P.R. China.
Telephone: 86-25-86868450
Fax: 86-25-86868499
E-mail: cyzhong@njmu.edu.cn
2. Education
INSTITUTION | DEGREE | MM/YY | FIELD OF STUDY |
Southeast University Medical School | B.S. | 07/84 | Medicine |
Nanjing Medical University | M.S. | 07/87 | Nutrition and Food Hygiene |
University of California, Davis, USA | Ph.D. | 03/05 | Comparative Pathology |
3. Research Interests
My research interests mainly focus on diet, nutrition and cancer. Currently, my research efforts are exploring the mechanisms by which dietary factors prevent and/or promote cancer development. In particular, I am interested in understanding the mechanisms of carcinogenesis, the action of dietary factors in cancer initiation and progression, and the anti-carcinogenic potential of dietary components especially phytochemicals for cancer intervention.
4. Selected Publications
(1) Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Ma X, Geng S, Wu J, Zhong C. Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells. Biochem Biophys Res Commun. 2016. doi: 10.1016/j.bbrc.2016.11.038.
(2) Geng S, Zhu W, Xie C, Li X, Wu J, Liang Z, Xie W, Zhu J, Huang C, Zhu M, Wu R, Zhong C. Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice. Eur J Nutr. 2016;55(3):931-40.
(3) Zhu M, Huang C, Ma X, Wu R, Zhu W, Li X, Liang Z, Deng F, Zhu J, Xie W, Yang X, Jiang Y, Wang S, Wu J, Geng S, Xie C, Zhong C. Modulation of miR-19 in Aluminum-Induced Neural Cell Apoptosis. J Alzheimers Dis. 2016;50(4):1149-62.
(4) Deng QF, Sun X, Liang ZF, Zhang ZQ, Yu DX, Zhong CY. Cigarette smoke extract induces the proliferation of normal human urothelial cells through the NF-κB pathway. Oncol Rep. 2016; 35(5):2665-72.
(5) Sun X, Deng QF, Liang ZF, Zhang ZQ, Zhao L, Geng H, Xie DD, Wang Y, Yu DX, Zhong CY. Curcumin reverses benzidine-induced cell proliferation by suppressing ERK1/2 pathway in human bladder cancer T24 cells. Exp Toxicol Pathol. 2016; 68(4):215-22.
(6) Zhu M, Li B, Ma X, Huang C, Wu R, Zhu W, Li X, Liang Z, Deng F, Zhu J, Xie W, Yang X, Jiang Y, Wang S, Wu J, Geng S, Xie C, Zhong C, Liu H. Folic Acid Protected Neural Cells Against Aluminum-Maltolate-Induced Apoptosis by Preventing miR-19 Downregulation. Neurochem Res. 2016;41(8):2110-8.
(7) Liang Z, Xie W, Wu R, Geng H, Zhao L, Xie C, Li X, Huang C, Zhu J, Zhu M, Zhu W, Wu J, Geng S, Zhong C. ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial-mesenchymal transition. Oncotarget. 2015;6(23):19605-18.
(8) Geng H, Zhao L, Liang Z, Zhang Z, Xie D, Bi L, Wang Y, Zhang T, Cheng L, Yu D, Zhong C. ERK5 positively regulates cigarette smoke-induced urocystic epithelial-mesenchymal transition in SV‑40 immortalized human urothelial cells. Oncol Rep. 2015;34(3):1581-8.
(9) Liang Z, Wu R, Xie W, Geng H, Zhao L, Xie C, Wu J, Geng S, Li X, Zhu M, Zhu W, Zhu J, Huang C, Ma X, Zhong C, Han H. Curcumin Suppresses MAPK Pathways to Reverse Tobacco Smoke-induced Gastric Epithelial-Mesenchymal Transition in Mice. Phytother Res. 2015;29(10):1665-71.
(10) Zhao L, Geng H, Liang ZF, Zhang ZQ, Zhang T, Yu DX, Zhong CY. Benzidine induces epithelial-mesenchymal transition in human uroepithelial cells through ERK1/2 pathway. Biochemical and Biophysical Research Communications. 2015; 459(4):643-9.
(11) Liang Z, Xie W, Wu R, Geng H, Zhao L, Xie C, Li X, Zhu M, Zhu W, Zhu J, Huang C, Ma X, Wu J, Geng S, Zhong C, Han H. Inhibition of tobacco smoke-induced bladder MAPK activation and epithelial-mesenchymal transition in mice by curcumin. Int J Clin Exp Pathol. 2015;8(5):4503-13.
(12) Xie C, Li X, Wu J, Liang Z, Deng F, Xie W, Zhu M, Zhu J, Zhu W, Geng S, Zhong C. Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway. Inflammation. 2015;38(4):1639-48.
(13) Li X, Xie W, Xie C, Huang C, Zhu J, Liang Z, Deng F, Zhu M, Zhu W, Wu R, Wu J, Geng S, Zhong C. Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation. Phytother Res. 2014;28(10):1553-60.
(14) Li Z, Zhong C and Hu C. Food and Nutritional Components in Focus No. 5 Isoflavones: Chemistry, Analysis, Function and Effects. Chapter 35 Equol and Cell Proliferation. p580-596. Edited by Victor R Preedy. The Royal Society of Chemistry, 2012.
(15) Du J,Zhou N, Liu H, Jiang F, Wang Y, Qi H,Zhong C, Wang S, Liu Q, Wang X, Li Z. Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer. PloS One. 2012; 7(4):e35957. expression in response to delayed anesthetic preconditioning. AGE. 2012; 34(6):1459-72.
(16) Pan MX, Han HY, Zhong CY, Geng QS. Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line. The Journal of Nutrition, Health & Aging. 2012; 16(4):389-94.
(17) Han H, Zhong CY, Zhang X, Liu R, Pan M, Tan L, Li Y, Yang S, Zuo Y, Huang W. Genistein induces growth inhibition and G2/M arrest in nasopharyngeal carcinoma cells. Nutrition and Cancer. 2010; 62(5):641 -647.
(18) Zhong CY, Zhou YM, Smith KR, kennedy IM, Chen C, Aust AE, Pinkerton, KE. Oxidative injury in the lungs of neonatal rats following short term exposure to ultrafine iron and soot particles. Journal of Toxicology and Environmental Health. 2010;73(12):837–847.
(19) Miao XS, Zhong CY, Wang YX, Savage RE, Yang RY, Kizer D, Volckova E, Ashwell MA, Chan TCK. In vitro metabolism of b-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells. Rapid Communications in Mass Spectrometry. 2009;23 (1): 12-22.
(21) Wang L, Joad JP, Zhong CY, Pinkerton KE. Effects of early exposure to environmental tobacco smoke on type 1 immune responses in the lung of infant monkeys. Journal of Allergy and Clinical Immunology. 2008; 122 (2):400-406.
(22) Zhong CY, Zhou YM, Pinkerton KE. NF-kB inhibition is involved in tobacco smoke-induced apoptosis in the lungs of rats. Toxicology and Applied Pharmacology. 2008;230 (2): 150-158.
(23) Miao XS, Song PF, Savage R, Zhong CY, Yang RY, Kizer D, Wu H, Volckova E, Ashwell MA, Supko JG, He X, Chan TCK. Identification of the in Vitro Metabolites of 3,4-Dihydro-2,2-dimethyl-2H-naphthol[1,2-b] pyran- 5,6 – dione (ARQ 501; b-Lapachone) in Whole Blood. Drug Metabolism and Disposition. 2008; 36: 641-648.
(24) Pinkerton KE, Zhou YM, Zhong CY, Smith KR, Teague SV, Kennedy IM, Ménache MG. Mechanisms of particulate matter toxicity in neonatal and young adult rat lungs. Health Effect Institute Research Report 135, 2008,Boston, MA, USA
(25) Zhong CY, Zhou YM, Joad JP, Pinkerton KE. Environmental tobacco smoke suppresses nuclear factor-kappaB signaling to increase apoptosis in infant monkey lungs. American Journal of Respiratory and Critical Care Medicine. 2006; 174 (4): 428-436.
(26) Zhong CY, Zhou YM, Douglas GC, Witschi H, Pinkerton E. MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats. Carcinogenesis. 2005;26(12):2187-2195.
(27) Zhong CY, Zhou YM, Liu H. Nuclear factor kB and anesthetic preconditioning during myocardial ischemia-reperfusion. Anesthesiology. 2004;100: 540-546.
(28) Zhou YM, Zhong CY, Leppert VJ, Kennedy IM and Pinkerton KE. Oxidative stress and NF-kB activation in the lungs of rats: a synergistic interaction between soot and transition metal iron. Toxicology and Applied Pharmacology. 2003; 190(2): 157-169.
(29) Zhou YM, Zhong CY, Kennedy IM and Pinkerton KE.Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats. Environmental Toxicolog. 2003; 18:227-235.
5. Scholarly and Professional Activities
Diplomate of the American Board of Toxicology (D.A.B.T.)
Member, American Association for Cancer Research
Member, Society of Toxicology
