Feng Qing
1. Personal Information
Title/Position: Professor/Deputy Chairman
Correspondence Address: Department of Hygiene Analysis and Detection, Nanjing Medical University, 101 Longmian Av., Jiangning District, Nanjing, Jiangsu Province, 211166, P.R. China.
Telephone: 86-25-86868455
E-mail: qingfeng@njmu.edu.cn
2. Education
DEGREE | MM/YY | FIELD OF STUDY | |
Nanjing Agriculture University | B.S. | 07/89 | Food Science |
Nanjing Agriculture University | M.S. | 07/96 | Biochemistry |
Nagoya University, Nagoya, Japan | Ph.D. | 03/02 | Applied Molecular Biology |
University of New Hampshire, NH, USA | Postdoctor | 07/03 | Biochemistry and Molecular Biology |
Dartmouth Medical School, NH, USA | Research Associate | 11/08 | Pharmacology and Toxicology |
3. Research Interests
My group focuses on the effect of dietary phytochemicals on chronic disease prevention, as well as the protective effect of the phytochemicals against environmental toxicity. We have found that green tea polyphenol EGCG and curcumin can up-regulate the tumor suppress gene such as UBE1L or JWA and therefore down-regulate oncogene EGFR. Also, Combination of EGCG and cisplatin enhance the sensitivity of the cancer cells to chemotherapy. In addition, EGCG, curcumin and oleuropein are found to protect hepatocytes and myocardial cells against acrylamide.
4. Selected Publications (Corresponding Author)
1. Jiang P, Wu X, Wang X, Huang W, Feng Q. NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells. Oncotarget, 2016, 7, 43337-43351.
2. Li Y, Shen X, Wang X, Li A, Wang P, Jiang P, Zhou J, Feng Q. EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells. Sci Rep. 2015, 5:11009. (Corresponding Author)
3. Jiang A, Wang X, Shan X, Li Y, Wang P, Jiang P, Feng Q. Curcumin Reactivates Silenced Tumor Suppressor Gene RARβ by Reducing DNA Methylation. Phytother Res. 2015 29(8):1237-45. (Corresponding Author)
4. Li X, Li Y, Shen X, Fu S, Han S, Feng Q. All-trans retinoic acid suppresses topoisomerase IIα through the proteasomal pathway. Anticancer Drugs. 2015, 26(7):737-46.(Corresponding Author)
5. Wang X, Jiang P, Wang P, Yang CS, Wang X, Feng Q. EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer. PLoS One. 2015, 10(4):e0125402. (Corresponding Author)
6. Jiang A, Li Y, Wang P, Shan X, Jiang P, Wang X, Feng Q. Mechanism of dose-dependent regulation of UBE1L by polyphenols in human bronchial epithelial cells. J Cell Biochem. 2015,116(8):1553-62. (Corresponding Author)
7. Yang CS, Feng Q. Chemo/Dietary prevention of cancer: perspectives in China.J Biomed Res. 2014, 28(6): 447-455. (Corresponding Author)
8. Zhou DH, Wang X, Feng Q. EGCG enhances the efficacy of cisplatin by downregulating hsa-miR-98-5p in NSCLC A549 cells. Nutr Cancer. 2014, 66(4): 636-644.(Corresponding Author)
9. Shan X, Li Y, Meng X, Wang P, Jiang P, Feng Q. Curcumin and (-)-epigallocatechin-3-gallate attenuate acrylamide-induced proliferation in HepG2 cells. Food Chem Toxicol. 2014, 66: 194-202.(Corresponding Author)
10. Jiang AP, Zhou DH, Meng XL, Zhang AP, Zhang C, Li XT, Feng Q. Down-regulation of epidermal growth factor receptor by curcumin-induced UBE1L in human bronchial epithelial cells. J Nutr Biochem. 2014, 25(2): 241-249. (Corresponding Author)
11. Zhou D, Wang X, Yang M, Shi X, Feng Q.Combination of low concentration of EGCG and curcumin strongly suppresses the growth of non-small cell lung cancer in vitro and in vivo through causing cell cycle arrest. Int J Mol Sci. 2013, 14: 12023 -12036. (Corresponding Author)
5. Scholarly and Professional Activities
MEMBER: of American Nutrition Society; of China Nutrition Society
MEMBER: of American Association of Cancer Research
EXCUTIVE COUNCIL MEMBER: of Jiangsu (China) Biochemistry and Molecular Biology
