Zhou Jianwei
1.Personal Information
Title/Position: Professor
Correspondence Address: Correspondence Address:Department of Occupational Medicine and Environmental Health, Nanjing Medical University, 101 Longmian Av., Jiangning District, Nanjing, Jiangsu Province, 211166, P.R. China.
Telephone: +86-25-8686 9108(Office) / 8686 8421 (Lab)
E-mail: jwzhou@njmu.edu.cn
2. Education
INSTITUTION | DEGREE | MM/YY | FIELD OF STUDY |
Nanjing Medical University | B.S. | 11/82 | Preventive Medicine |
Nanjing Medical University | Ph.D. | 06/03 | Occupational & Environmental Health |
SunYet-sen University of Medicine Sciences | Visiting Scholar | 08/93-07/94 | Public Health |
University of California, Davis | Visiting Scholar | 03/96-03/98 | Molecular & Cell Biology |
3. Research Interests
I am currently conducting research in following areas: (1) Interactions between Environmental exposures and genes. (2) The mechanisms of conditional knockout JWA induced changes of microenvironment on tumor growth and metastasis. (3) The sequential strategies to inhibit gastric cancer/melanoma metastasis via JWA/MDM2 based signaling networks.
4. Selected Publications (* Corresponding Author)
1.Chen, R., Qiu, W., Liu, Z., Cao, X., Zhu, T., Li, A., Wei, Q., and Zhou, J*. (2007). Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide. Free Radic Biol Med 42, 1704-1714.
2.Chen, H., Bai, J., Ye, J., Liu, Z., Chen, R., Mao, W., Li, A., and Zhou, J*. (2007). JWA as a functional molecule to regulate cancer cells migration via MAPK cascades and F-actin cytoskeleton. Cell Signal 19, 1315-1327.
3.Wang, S., Gong, Z., Chen, R., Liu, Y., Li, A., Li, G., and Zhou, J*. (2009). JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks. Nucleic Acids Res 37, 1936-1950.
4.Bai, J., Zhang, J., Wu, J., Shen, L., Zeng, J., Ding, J., Wu, Y., Gong, Z., Li, A., Xu, S.,Zhou, J*., Li, G.(2010). JWA regulates melanoma metastasis by integrin alphaVbeta3 signaling. Oncogene 29, 1227-1237.
5.Chen, Y., Huang, Y., Huang, Y., Xia, X., Zhang, J., Zhou, Y., Tan, Y., He, S., Qiang, F., Li, A.,Zhou, J*. (2014). JWA suppresses tumor angiogenesis via Sp1-activated matrix metalloproteinase-2 and its prognostic significance in human gastric cancer. Carcinogenesis 35, 442-451.
6.Wang, S., Wu, X., Chen, Y., Zhang, J., Ding, J., Zhou, Y., He, S., Tan, Y., Qiang, F., Bai, J., Zhou, J*. (2012). Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer. Clin Cancer Res 18, 2987-2996.
7.Xu, W., Chen, Q., Wang, Q., Sun, Y., Wang, S., Li, A., Xu, S., Roe, O. D., Wang, M., Zhang, R., Zhou, J*. (2014). JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells. Cell Death Dis 5, e1551.
8.Huang, Y., Chen, R., and Zhou, J*. (2016). E2F1 and NF-kappaB: Key Mediators of Inflammation-associated Cancers and Potential Therapeutic Targets. Curr Cancer Drug Targets 16, 765-772.
5. Scholarly and Professional Activities
1. Active member, American Association of Cancer Research (AACR)
2. Vice President, Chinese Society of Toxicology
3. President, Jiangsu Society of Toxicology
4. Associate Editor, Journal of Toxicology and Environmental Health, Part B
5. Editorial board member, Current Cancer Drug Targets
