倪春辉

Ni Chunhui

1. Personal Information

Title/Position: Professor, Deputy Director

Correspondence Address:Department of Occupational Medicine

and Environmental Health, Nanjing Medical University, 101

Longmian Av., Jiangning District, Nanjing, Jiangsu Province, 211166,

P.R. China.

Telephone:0086-25-86868418

Fax: 0086-25-86868499

E-mail: chni@njmu.edu.cn

2. Education

3. Research Interests

    My research activities are lung fibrosis, especially coal workers’ pneumoconiosis and silicosis, and carbon disulfide (CS₂) poisoning. The main research is in pathogenic mechanisms and individual susceptibility of coal workers’ pneumoconiosis which involve in population study, cell lines and animal models. Since 2008, six grants have been gained, in which four are from National Natural Science Foundation (NSFC) and two from Health Department of Jiangsu Province, and more than 70 papers as the correspond author or first author have been published including 26 papers which published in English Journals.

4. Selected Publications

1. Yang JJ, Wang T, Ji XM, Han RH, Wu QY, Yan Yan, Yuan JL, Han L, Ni CH*. Earthworm Extract Attenuates Silica-Induced Pulmonary Fibrosis through Nrf2 dependent Mechanisms.Lab Invest.2016.101 ( online)

2. Wu QY, Yan Yan, Han RH, Yang JJ, Yuan JL, Ji XM, Yi Liu, Ni CH*. Polymorphisms in long non-coding RNA H19 and Coal Workers’ Pneumoconiosis risk in a Chinese population.Int. J. Environ. Res. Public Health. 2016,13(9),903.

3. Han RH, Ji XM, Rong R, Wu QYYang JJ, Yan Y, Han L, Yuan JL, Ni CH*. MiR-449a regulate autophagy to inhibit silica-induced pulmonary fibrosis through targeting of Bcl2.J Mol Med, 2016.94(11):1267-1279

4. Wu QY, Han L, Yan Yan, Ji XM, Han RH, Yang JJ, Yuan JL, Ni CH*. miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF. Scientific Report. 2016.6(8):30921

5. Luo C, Ji XM, Fan JJ, Hou ZG, Wang T, Wu BQ, Ni CH*.Annexin A5 promotes macrophage activation and contributes to pulmonary fibrosis induced by silica particles.Toxicol Ind Health, 2016，32（9）:1628-38

6. Han RH, Ji XM, Wu BQ, Wang T, Han L, Yang JJ, Zhu BL, Ni CH*. Polymorphisms in Interleukin 17A Gene and Coal Workers’ Pneumoconiosis Risk in a Chinese Population. BMC Pulmonary Medicine,2015,15:79

7. Yang JJ, Wang LJ, Wang T,Chen CC, Ji XM, Wu BQ, Han RH, Han L, Ni CH*. Associations of MMP-7 and OPN Gene Polymorphisms with Risk of Coal Workers' Pneumoconiosis in a Chinese Population. Inhal Toxicol, 2015 ,27(12):641-648

8. Ji XM, Wang LJ, Wu BQ, Han RH, Han L, Wang T, Yang JJ and Ni CH*.Associations of MMP1, MMP2 and MMP3 Genes Polymorphism with Coal Workers’ Pneumoconiosis in Chinese Han Population. Int. J. Environ. Res. Public Health,2015,12: 13901-13912

9. Ji XM, Wu BQ, Fan JJ, Han RH, Luo C, Wang T, Yang JJ,Han L, Zhu BL, Dong Wei, Jingyu Chen,Ni CH*. The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis.Scientific Report,2015,5(9):14131

10. Han L, Ji XM, Han RH, Wang T, Yang JJ, Yuan JL, Wu QY, Zhu BL, Hengdong Zhang, Bangmei Ding, Ni CH*. Prevalence Characteristics of Coal Workers’ Pneumoconiosis (CWP) in a State-owned Mine in the East of China. Int. J. Environ. Res. Public Health 2015, 12, 7856-7867.

11. Guo L, Luo C, Fan J, Hou Z, Ji X, Chen F*, Zhu B*, Ni C*. Serum miRNA Profiling Identifies miR-150/30a as Potential Biomarker for Workers with Damaged Nerve Fibers from Carbon Disulfide.Ind Health,2015,53:38-47.

12. Wang T, Yang JJ, Ji XM, Chu MJ, Zhang RY, Dai JC, Jin GF, Hu ZB, Shen HB & Ni CH*.Pathway analysis for a genome-wide association study ofpneumoconiosis.Toxicology Letter,2015,232(1):284-292.

13. Wu BQ, Ji XM, Han RH, Han L, Wang T, Yang JJ, Zhu BL, Ni CH*. GITR Promoter Polymorphism Contributes to Risk of Coal Workers’ Pneumoconiosis: A Case-control Study From China.Immunology Letters.2014 Dec;162(10):210-216. IF=2.48

14. Wang T, Yang JJ, Han RH, Ji XM, Wu BQ, Han L, Luo C, Fan JJ，Zhu BL，Ni CH*. Polymorphisms in SPARC and Coal Workers’ Pneumoconiosis Risk in a Chinese Population. PLOS ONE，2014,9（8）:e105226（IF=3.543）

15. Chu MJ, Ji XM, Chen WH, Zhang RY, Hou ZG, Luo C, Gong JH, Zhu M, Sun CQ, Fan JJ, Wang T, Dai JC, Jin GF, Wu TC, Chen F, Hu ZB*, Ni CH* & Shen HB*. A genome-wide association study identifies three susceptibility loci of silica related pneumoconiosis in Han Chinese. Hum Mol Genet.2014 Dec 1;23:6385-94.IF=6.677

16. Ji XM, Wu BQ, Jin KX, Luo C, Han RH, Chen MJ, Hou ZG, Fan JJ, Ni CH. MUC5B Promoter Polymorphisms and Risk of Coal Workers’ Pneumoconiosis in a Chinese Population. Molecular Biology Reports. 2014 ,41(7):4171-4176.

17. Wang T, Ji XM , Luo C, Fan JJ, Hou ZG, Chen MJ, Han RH, Ni CH*. Polymorphisms in SELE gene and risk of coal workers’ pneumoconiosisin Chinese: A Case-Control Study. PLOS ONE，2013,8(9):e73254.

18. Guo L, Ji XM, Yang S, Hou ZG, Luo C, Fan JJ, Ni CH*, Chen F*. Genome-wide analysis of aberrantly expressed circulating miRNAs in patients with coal workers' pneumoconiosis. Molecular Biology Reports.2013,40:3739-47

19. Ji XM, Hou ZG, Wang T, Jin KX, Fan JJ, Luo C, Chen MJ, Han RH , Ni CH*. Polymorphisms in Inflammasome Genes and Risk of Coal Workers’ Pneumoconiosis in a Chinese Population. PLOS ONE，2012, 7(10): e47949

20. Jin KX, Ji XM, Wang SS, Song ZF, Jia XM, Hou ZG, Wang T, Wang ML, Ni CH*.The MIF -173G/C Polymorphism and Risk of Coal Workers’ Pneumoconiosis in a Chinese Population. International Journal of Interferon, Cytokine and Mediator Research,2012,4(5):37-42

21. Wang ML, Wang SS, Song ZF, Jia XM, Zhang ZD, Zhou JW, Ni CH*. Associations of IL-4, IL-4R, and IL-13 gene polymorphisms in coal workers’ pneumoconiosis in China: a case-control study. PLOS ONE，2011,6(8):e22624

22. Wang ML, Ye Y, Qian HY, Song ZF, Jia XM, Zhang ZD, Zhou JW, Ni CH*. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. J Hum Genet. 2010;55(1):13-17

23. Ni CH, Ye Y, Wang ML, Qian HY, Song ZF, Jia XM, Zhou JW. A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with risk of coal workers' pneumoconiosis.J Toxicol Environ Health A. 2009;72(11):712-6