Chen Feng
1. Personal Information
Title/Position: Professor, Dean of School of Public Health
Correspondence Address:
Dept. of Biostatistics, Nanjing Medical University
101 Longmian Av., Jiangning District
Nanjing, Jiangsu Province, 211166, P.R. China.
Telephone: 86-25-8686-8435
E-mail: fengchen@njmu.edu.cn
2. Education
INSTITUTION | DEGREE (if applicable) | MM/YY | FIELD OF STUDY |
Sun Yat-Sen University, | B.S. | 06/1983 | Math |
Shanghai Second Medical College | M.S. | 06/1989 | Biostatistics |
West China University of Medical Sciences | Ph.D. | 06/1994 | Biostatistics |
3. Research Interests
I am currently conducting research in multiple omics data, causal inference, and cancer risk/prognosis.
Selected grants:
1)Principal Investigator, Biomedical multidimensional data integration method based on the population and tumor risk prediction research. National Natural Science Foundation of China (NSFC), 81530088, 2016-2020,
2)Principal Investigator, Genome-wide association studies of gene - statistical analysis method, gene-environment interaction research. National Natural Science Foundation of China (NSFC), 81473070, 2015-2018,
3)Principal Investigator, Gene-gene and gene-environment interaction analysis based on big data of medicine. Key Project of Natural Science Foundation of Jiangsu,14KJA310002, 2014-2016,
4)Principal Investigator, On statistical methods for genome-wide association study. National Natural Science Foundation of China (NSFC), 81072389, 2011~2013,
5)Principal Investigator, On statistical methods for high-dimensional biological data. Key Project of Natural Science Foundation of Jiangsu, 10KJA33034, 2011~2013,
4. Selected Publications
1)Yi H, Wo H, Zhao Y, Zhang R, Dai J, Jin G, Ma H, Wu T, Hu Z, Lin D, Shen H, Chen F*. Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study: principal components analysis vs. partial least squares. J Biomed Res. 2015 Jul;29(4):298-307.
2)Yang S, Li H, Ge Q, Guo L, Chen F*. Deregulated microRNA species in the plasma and placenta of patients with preeclampsia. Mol Med Rep. 2015 Jul;12(1):527-34.
3)Yang S, Guo L, Shao F, Zhao Y, Chen F. A Systematic Evaluation of Feature Selection and Classification Algorithms Using Simulated and Real miRNA Sequencing Data. Comput Math Method M. 2015.
4)Zeng P, Zhao Y, Qian C, Zhang L, Zhang R, Gou J, Liu J, Liu L, Chen F. Statistical analysis for genome-wide association study. J Biomed Res. 2015 Jul;29(4):285-97.
5)Liu LY, Yu H, Bai JL, Zeng P, Miao DD, Chen F*. Verification of the correlation between progression-free survival and overall survival considering magnitudes of survival post- progression in the treatment of four types of cancer. Asian Pac J Cancer Prev. 2015;16(3):1001-6.
6)Zeng P, Zhao Y, Li H, Wang T, Chen F*. Permutation-based variance component test in generalized linear mixed model with application to multilocus genetic association study. BMC Med Res Methodol. 2015 Apr 22;15:37.
7)Yu P, Huang L, Li H, Liu M, Zong J, Li C, Chen F*. Epidemiological investigation of an outbreak of hepatitis A in rural China. Int J Infect Dis. 2015 Apr;33:191-5.
8)Zhang H, Yang S, Guo L, Zhao Y, Shao F, Chen F*. Comparisons of isomiR patterns and classification performance using the rank-based MANOVA and 10-fold cross-validation. Gene. 2015 Sep 10;569(1):21-6.
9)Yang S, Zhang H, Guo L, Zhao Y, Chen F*. Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer. Gene.2014 Sep 10;548(1):6-13.
10)Guo L, Chen F*. A challenge for miRNA: multiple isomiRs in miRNAomics. Gene. 2014 Jul 1;544(1):1-7.
11)Liu J, Chen F*, Yu H, Zeng P, Liu L. A two-stage Bayesian method for estimating accuracy and disease prevalence for two dependent dichotomous screening tests when the status of individuals who are negative on both tests is unverified. BMC Med Res Methodol. 2014,14:110.
12)Gou J, Zhao Y, Wei Y, Wu C, Zhang R, Qiu Y, Zeng P, Tan W, Yu D, Wu T, Hu Z, Lin D, Shen H, Chen F*. Stability SCAD: a powerful approach to detect interactions in large-scale genomic study. BMC Bioinformatics. 2014,15:62.
13)Chu M, Zhang R, Zhao Y, Wu C, Guo H, Zhou B, Lu J, Shi Y, Dai J, Jin G, Ma H, Dong J, Wei Y, Wang C, Gong J, Sun C, Zhu M, Qiu Y, Wu T, Hu Z, Lin D, Shen H*, Chen F*. A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese. Carcinogenesis. 2014,35(3):572-7.
14)Zhang R, Chu M, Zhao Y, Wu C, Guo H, Shi Y, Dai J, Wei Y, Jin G, Ma H, Dong J, Yi H, Bai J, Gong J, Sun C, Zhu M, Wu T, Hu Z, Lin D, Shen H*, Chen F*. A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility. Carcinogenesis. 2014,35(7):1528-35.
15)Zeng P, Wei Y, Zhao Y, Liu J, Liu L, Zhang R, Gou J, Huang S, Chen F*. Variable selection approach for zero-inflated count data via adaptive lasso. J Appl Stat. 2014,41(4):879-94.
16)Zeng P, Zhao Y, Zhang L, Huang S, Chen F*. Rare Variants Detection with Kernel Machine Learning Based on Likelihood Ratio Test. PLoS One. 2014,9(3):e93355.
17)Zeng P, Zhao Y, Liu J, Liu L, Zhang L, Wang T, Huang S, Chen F*. Likelihood ratio tests in rare variant detection for continuous phenotypes. Ann Hum Genet. 2014,78(5):320-32.
18)Guo L*, Zhao Y, Yang S, Zhang H, Chen F*. An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles. BioMed Res Int. 2014, http://dx.doi.org/10.1155/2014/345605.
19)Guo L, Yang S, Zhao Y, Zhang H, Wu Q*, Chen F*.Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression. BioMed Res Int. 2014,http://dx.doi.org/10.1155/2014/782490.
20)Guo L, Zhao Y, Yang S, Zhang H, Wu Q, Chen F*. An Integrated Evolutionary Analysis of miRNA-lncRNA in Mammals. Mol Biol Rep. 2014,41(1):201-7.
21)Guo L, Zhao Y, Yang S, Zhang H, Chen F*. A genome-wide screen for non-template nucleotides and isomiR repertoires in miRNAs indicates dynamic and versatile microRNAome. Mol Biol Rep. 2014,41:6649-58.
22)Guo L, Zhang H, Zhao Y, Yang S, Chen F*. In-depth exploration of miRNA: a new approach to study miRNA at the miRNA/isomiR levels. Curr Bioinform. 2014,9:522-30.
23)Guo L, Zhao Y, Zhang H, Yang S, Chen F*. Integrated evolutionary analysis of human miRNA gene clusters and families implicates evolutionary relationships. Gene. 2014,534(1):24-32.
24)Guo L, Zhao Y, Yang S, Zhang H, Chen F*. Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions. BioMed Res Int. 2014,http://dx.doi.org/10.1155/2014/907420.
25)Guo L, Zhang H, Zhao Y, Yang S, Chen F*. Selected isomiR expression profiles via arm switching? Gene. 2014,533(1):149-55.
26)Guo L, Ji X, Yang S, Hou Z, Luo C, Fan J, Ni C*, Chen F*. Genome-wide analysis of aberrantly expressed circulating miRNAs in patients with coal workers’ pneumoconiosis. Mol Biol Rep. 2013,40:3739-47.
27)Guo L, Zhao Y, Zhang H, Yang S, Chen F*. Close association between paralogous multiple isomiRs and paralogous/orthologues miRNA sequences implicates dominant sequence selection across various animal species. Gene. 2013,527:624-9.
28)Guo L, Zhao Y, Yang S, Wu Q, Chen F*. Dynamic Evolution of mir-17-92 Gene Cluster and Related miRNA Gene Families in Vertebrates. Mol Biol Rep. 2013,40:3147-53.
29)Zhang R, Zhao Y, Chu M, Mehta A, Wei Y, Liu Y, Xun P, Bai J, Yu H, Su L, Zhang H, Hu Z, Shen H, Chen F*, Christiani, DC*. A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure. PLoS One. 2013,8(3):e59035.
30)Cai M Dai H, Qiu Y, Zhao Y, Zhang R, Chu M, Dai J, Hu Z, Shen H, Chen F*. SNP set association analysis for genome-wide association studies. PLoS One. 2013,8(5):e62495.
31)Dai H, Zhao Y, Qian C, Cai M, Zhang R, Chu M, Dai J, Hu Z, Shen H, Chen F*. Weighted SNP set analysis in genome-wide association study. PLoS One. 2013,8(9):e75897.
32)Zhang R, Zhao Y, Chu M, Wu C, Jin G, Dai J, Wang C, Hu L, Gou J, Qian C, Bai J, Wu T, Hu Z, Lin D, Shen H, Chen F*. Pathway analysis for genome-wide association study of lung cancer in Han Chinese population. PLoS One. 2013,8(3):e57763.
33)Guo L, Zhao Y, Yang S, Cai M, Wu Q*, Chen F*. Genome-wide screen for aberrantly expressed miRNAs reveals miRNA profile signature in breast cancer. Mol Biol Rep. 2013,40:2175-86.
34)Li Guo, Beili Sun, Qian Wu, Sheng Yang, Feng Chen*. amiRNA–miRNA interaction implicates for potential mutual regulatory pattern. Gene, 2012. 511:187–194
35)Yang Zhao, Hao Yu, Ying Zhu, Monica Ter-Minassian, Zhihang Peng, Hongbing Shen, Nancy Diao, Feng Chen*. Genetic Association Analysis Using Sibship Data: A Multilevel Model Approach. PLoS one. 2012, 7(2):e31134
36)Zhi-Hang Peng, Yue-Jia Cheng, Kathleen H. Reilly, Lu Wang, Qian-Qian Qin, Zheng-Wei Ding, Guo-Wei Ding, Ke-Qin Ding, Rong-Bin Yu, Feng Chen, Ning Wang. Spatial distribution of HIV/AIDS in Yunnan province, People’s Republic of China. Geospatial Health, 2012, 5(2): 177-182
37)Zhao Y, Chen F, Zhai R, Lin X, Diao N, et al. Association Test Based on SNP Set: Logistic Kernel Machine Based Test vs. Principal Component Analysis. PLoS ONE. 2012 7(9): e44978. doi:10.1371/journal.pone.0044978
38)Jing Dong, Zhibin Hu, Chen Wu, Huan Guo, Baosen Zhou, Jiachun Lv, Daru Lu, Kexin Chen, Yongyong Shi, Minjie Chu, Cheng Wang, Ruyang Zhang, Juncheng Dai, Yue Jiang, Songyu Cao, Zhenzhen Qin, Dianke Yu, Hongxia Ma, Guangfu Jin, Jianhang Gong, Chongqi Sun, Xueying Zhao, Zhihua Yin, Lei Yang, Zhiqiang Li, Qifei Deng, Jiucun Wang, Wei Wu, Hong Zheng, Guoquan Zhou, Hongyan Chen, Peng Guan, Zhihang Peng, Yijiang Chen, Yongqian Shu, Lin Xu, Xiangyang Liu, Li Liu, Pin Xu, Baohui Han, Chunxue Bai, Yuxia Zhao, Haibo Zhang, Ying Yan, Christopher I Amos, Feng Chen, Wen Tan, Li Jin, Tangchun Wu, Dongxin Lin & Hongbing Shen. Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nature Genetics, 2012,44( 8) , 895~899
39)Zhao Y, Yu H, Zhu Y, Ter-Minassian M, Peng Z, Shen H, Diao N, Chen F. Genetic association analysis using sibship data: a multilevel model approach. PLoS One.2012;7(2):e31134. Epub 2012 Feb 1. PubMed PMID: 22312441; PubMed Central PMCID: PMC3270036.
5. Scholarly and Professional Activities
2009~Chairman of China Association of Biostatistics (CABS), China Health Information Association
2011~Chairman of China Clinical Trail Statistics Working Group (CCTS group)
2013~Vice President of IBS-China (International Biometric Society - China )
2002~ Reviewer for State Food and Drug Administration (SFDA)
1999~2003 Member of Drafting Committee for Statistical Principle in Clinical Trials, State Food and Drug Administration (SFDA)
2005~Member of International Chinese Statistics Association (ICSA)
2006~Chairman of Jiangsu Biostatistics Society
