刘起展

Liu Qizhan

1. Personal Information

Title/Position: Professor, Director of Department of Toxicology

Correspondence Address: 101 Longnian Avenue, Jiangning District,

Nanjing 211166, P. R. China

Telephone: 86-25-86868424

Fax: 86-25-86868499

E-mail: qzliu@njmu.edu.cn

2. Education

3. Research Interests

I am currently conducting research in two areas: (1) environmental toxicology and (2) the mechanism of chemical carcinogenesis.

4. Selected Publications

(1)Bairu Wang, Yi Liu, Fei Luo, Yuan Xu, Yu Qin, Xiaolin Lu, Wenchao Xu, Le Shi,Qizhan Liu*, and Quanyong Xiang*.Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract. Archive of Toxicology 2016, 90: 449-461.(IF=6.637)

(2) Yi Liu,Fei Luo, Bairu Wang, Huiqiao Li, Xuan Xu,Xinlu Liu,Le Shi,Xiaolin Lu, Wenchao Xu, Lu Lu, Yu Qin, Quanyong Xiang, and  Qizhan Liu*. STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells. Cancer Letters. 2016; 370(1): 125-135.(IF=5.992)

(3) Fei Luo, Xinlu Liu, Min Ling, Lu Lu, Le Shi, Xiaolin Lu, Jun Li, Aihua Zhang,and  Qizhan Liu*The lncRNA MALAT1, acting through HIF-1α stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cellsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016; 1862(9): 1685–1695.(IF=5.158)

(4)Fei Luo, Baofei Sun, Huiqiao Li, Xuan Xu,Yi Liu, Xinlu Liu, Lu Lu, Jun Li, Qingling Wang, Shaofeng Wei,Le Shi,Xiaolin Lu,Qizhan Liu*, and Aihua Zhang*.AMALAT1/HIF-2α feedback loop contributes to arsenite carcinogenesis. Oncotarget. 2016; 7(5): 5769-5789.(IF=5.008)

(5) Yuan Xu, Fei Luo, Yi Liu, Le Shi, Xiaolin Lu, Wenchao Xu, andQizhan Liu*. Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis. Archive of Toxicology.2015; 89(7): 1071-1082.(IF=6.637)

(6) Rongrong Jiang, Yuan Li, Yuan Xu, Yun Zhou, Ying Pang, Lu Shen, Yue Zhao, Jiangping Zhang, Jianwei Zhou, Xinru Wang, andQizhan Liu*.EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.Archive of Toxicology. 2013; 87 (6): 991-1000.(IF=5.078)

(7) Min Ling, Yuan Li, Yuan Xu, Ying Pang, Lu Shen, Rongrong Jiang,Yue Zhao, Xiaojun Yang, Jianping Zhang, Jianwei Zhou, Xinru Wang, andQizhan Liu*. Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation.Free Radical Biology & Medicine. 2012; 52: 1508-1518(IF=5.271)

(8) Yuan Xu, Yuan Li, Ying Pang, Min Ling, Lu Shen, Rongrong Jiang, Yue Zhao, Jianwei Zhou, Xinru Wang,andQizhan Liu*.Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells.Archive of Toxicology. 2012; 86: 947-959. (IF=5.215)

(9) Yuan Li, Yuan Xu, Min Ling, Ye Yang, Shoulin Wang, Zhong Li, Jianwei Zhou, Xinru Wang, andQizhan Liu*.Mot-2-mediated crosstalk between NF-κB and p53is involved in arsenite-induced tumorigenesis ofhuman embryo lung fibroblast cells. Environ Health Perspect. 2010; 118(7): 936-942.(IF=6.087)

(10) Yuan Li, Min Ling, Yuan Xu, Shoulin Wang, Zhong Li, Jianwei Zhou, Xinru Wang, andQizhan Liu*.The repressive effects of NF-κB on p53 by mot-2is involved in keratinocyte transformation induced by low levels of arsenite. Toxicologly Science. 2010; 116(1): 174-182.(IF=5.093)

5. Scholarly and Professional Activities

Director, Chinese Environmental Mutagen Society (CEMS).

Member, Endemiological Society of Chinese Medical Association (CMA).

Assistant Director, Biochemical and Molecular Tocicology Society of Chinese Toxicology Association (CTA).

Member, Immune Toxicologyocicology Society of Chinese Toxicology Association (CTA).