李忠

Li Zhong

  

1. Personal Information

Title/Position: Professor

Correspondence Address: Department of Social Medicine and Health Education, Nanjing Medical University, 101 Longmian Av.,Jiangning District, Nanjing, Jiangsu Province, 211166, P.R. China.

Telephone: 025-86868451

Fax: 025-86868451

E-mail:uiuclz@126.com

  

2. Education

INSTITUTION

DEGREE

MM/YY

FIELD OF STUDY

Huazhong Agricultural University

B.S.

07/90

Food Science

Huazhong Agricultural University

M.S.

07/95

Food Science

Huazhong Agricultural University

Ph.D.

07/98

Food Science

University of Illinois at UrbanaChampaign,IL, USA

Postdoctoral

08/05

Food Science &

Human Nutrition

 

3. Research Interests

I am currently conducting research in two areas: (1)Phytoestrogens and estrogen-dependent breast cancer and (2)Phytochemicals and metastasis, angiogenesis of human cancer.

  

4. Selected Publications

1. Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis. Sci Rep. 2016; 6: 36796.

2. Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: an epigenetic regulation of miR-148a/ SMAD2 signaling. Mol Carcinog. 2016; 55(5): 929-940

3. 14-3-3η is a novel growth-promoting and angiogenic factor in hepatocellular carcinoma. J Hepatol. 2016; 65(5): 953-962.

4. Isoliquiritigenin attenuates the invasive capacity of breast cancer cells via up-regulating the tumor suppressor RECK. RSC Adv. 2016; 6(1): 24719-24727.

5. The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol- induced angiogenesis in human breast cancer cells. Toxicol Lett. 2016; 264: 79-86

6. The repressive effect of miR-520a on NF-kB/IL-6/STAT-3 signal involvedin the glabridin-induced anti-angiogenesis in human breast cancer cells. RSC Adv. 2015; 5(1): 34257-34264

7. Effectiveness of a public dietitian-led diabetes nutrition intervention on glycemic control in a community setting in China. Asia Pacific J Clin Nutr. 2015, 24(3): 525-532

8. Induction of the mesenchymal to epithelial transition by demethylation- activated microRNA-200c is involved in the anti-migration/invasion effects of arsenic trioxide on human breast cancer cells. Mol Carcinog. 2014; 54(9): 859-869

8. Arsenic trioxide attenuates the invasion potential of human liver cancer cells through thedemethylation-activated microRNA-491. Toxicol Lett. 2014; 227(2): 75-83

9.Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer. PLoS ONE, 2012;7(4): e35957.

10. Delayed activation of extracellular-signal regulated kinase (ERK1/2) is involved in genistein- and equol-induced cell proliferation and estrogen receptor α-mediated transcription in MCF-7 breast cancer cells.J Nutr Biochem.2010; 21: 390-396.

11.Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2009; 113: 209-216.

12. Caffeine overcomes genistein-induced G2/M cell cycle arrest in breast cancer cells.Nutr Cancer.2008; 60: 382-388.