张正东

Zhang Zhengdong

  

1. Personal Information

Title/Position: Professor

Correspondence Address: Correspondence Address:Department of Occupational Medicine and Environmental Health, Nanjing Medical University, 101 Longmian Av., Jiangning District, Nanjing, Jiangsu Province, 211166, P.R. China.

Telephone: 025-86869220 (O)/025-86868423 (L)

E-mail: zdzhang@njmu.edu.cn

  

2. Education

INSTITUTION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

Nanjing Medical University

B.S.

07/87

Preventive Medicine

Shanghai Medical University

M.S.

07/94

Environment Health

Fudan Univerisity

Ph.D.

06/00

Labour Hygiene

University of Texas M. D. Anderson

Cancer Center, Houston, USA

Postdoctoral

Fellow

08/05

Molecular Epidemiology

 

3. Research Interests

I am currently conducting research in three areas: (1) Environment, Genetic/Epigenetic and Cancer; (2) Molecular Genetic Toxicology; (3) Occupational Harzard/Environmental Pollution and Human Health

 

4. Selected Publications (Corresponding Author)

1)Genome-Wide Association Study of Bladder Cancer in a Chinese Cohort Reveals a New Susceptibility Locus at 5q12.3. Cancer Res. 2016 Jun 1;76(11):3277-84

2)Identification of a novel susceptibility locus at 16q23.1 associated with childhood acute lymphoblastic leukemia in Han Chinese. Hum Mol Genet. 2016 Apr 19. pii: ddw112. [Epub ahead of print]

3)A functional variant in miR-143 promoter contributes to prostate cancer risk. Arch Toxicol. 2016 Feb;90(2):403-14.

4)Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Nat Commun. 2015 Oct 7;6:8469

5)Genetic variants in miRNAs predict bladder cancer risk and recurrence. Cancer Res. 2012 Dec 1;72(23):6173-82.

6)TERT polymorphisms modify the risk of acute lymphoblastic leukemia in Chinese children. Carcinogenesis. 2013 Jan;34(1):228-35

7)Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma. Ann Oncol. 2012 Aug;23(8):2114-21.

8)The polymorphisms in the VHL and HIF1A genes are associated with the prognosis but not the development of renal cell carcinoma. Ann Oncol. 2012 Apr;23(4):981-9.

9)Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population. Int J Cancer. 2011 Sep 1;129(5):1207-13.

10)A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer. Oncogene. 2010 Apr 1;29(13):1920-8.

11)A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer. Clin Cancer Res. 2009 Apr 1;15(7):2567-72.

12)A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population. Clin Cancer Res. 2008 Jun 1;14(11):3633-40.

 

5. Scholarly and Professional Activities

(1)Member of National Natural Science Foundation of Medical Sciences

(2)Member of Chinese Environmental Mutant Society

(3)Member of Jiangsu province Preventive Medicine

(4)Executive director and Deputy Secretary General of Jiangsu Province Environmental Mutagen Society