夏彦恺

Xia Yankai

  

1.  Personal Information

Title/Position: Professor/Vice Dean of SPH

Correspondence Address: Department of Toxicology, School of Public Health, Nanjing Medical University, 101 Longmian Av., Jiangning District, Nanjing, Jiangsu Province, 211166, P.R. China.

Telephone: 86-25-86868425

Fax: 86-25-8686-8427

E-mail: yankaixia@njmu.edu.cn

  

2.  Education

INSTITUTION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

Nanjing Medical University

B.Med./Medical Diploma

            07/01

Preventive Medicine

Nanjing Medical University

Ph.D.

06/07

Toxicology

Lawrence Berkeley National Laboratory (LBNL), University of California at Berkeley (UCB)

Visiting Scholar

06/11

Life Sciences

 

3.  Research Interests

(1)Early-life Environmental Exposure and Adverse Birth Outcomes

(2)Birth Cohort and Common Birth Defects

(3)Reproductive and Developmental Toxicology

(4)Nanotoxicology

  

4.  Selected Publications (2011-2016)

(1)Li X, Zhang C, Zhang X, Wang S, Meng Q, Wu S, Yang H, Xia Y*, Chen R*. An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles. Part Fibre Toxicol. 2016 Jan 16;13(1):4. IF=8.649

(2)Tang W, Tang J, Zhao Y, Qin Y, Jin G, Xu X, Zhu H, Shen H, Wang X, Hu Z*, Xia Y*. Exome-Wide Association Study Identified New Risk Loci for Hirschsprung's Disease. Mol Neurobiol. 2016 Feb 18. [Epub ahead of print]IF=5.397

(3)Tang W, Cai P, Huo W, Li H, Tang J, Zhu D, Xie H, Chen P, Hang B, Wang S, Xia Y*. Suppressive action of miRNAs to ARP2/3 complex reduces cell migration and proliferation via RAC isoforms in Hirschsprung disease. J Cell Mol Med. 2016 Mar 16. doi: 10.1111/jcmm.12799. [Epub ahead of print]

(4)Mao Z, Xu B, Ji X, Zhou K, Zhang X, Chen M, Han X, Tang Q, Wang X, Xia Y*. Titanium dioxide nanoparticles alter cellular morphology via disturbing the microtubule dynamics. Nanoscale. 2015 Apr 30;7(18):8466-75.IF=7.76

(5)Wang X, Chen X, Feng X, Chang F, Chen M, Xia Y*, Chen L*. Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice. Sci Rep. 2015 Dec 15;5:18252. IF=5.228

(6)Huo W, Cai P, Chen M, Li H, Tang J, Xu C, Zhu D, Tang W, Xia Y*. The relationship between prenatal exposure to BP-3 and Hirschsprung's disease. Chemosphere. 2015 Oct 7;144:1091-1097.IF=3.698

(7)Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B*, Xia Y*. Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2015 Oct 22;5:15512. IF=5.228

(8)Xu B, Mao Z, Ji X, Yao M, Chen M, Zhang X, Hang B, Liu Y, Tang W, Tang Q, Xia Y*. miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells. Sci Rep. 2015 Aug 11;5:12938.IF=5.228

(9)Chen X, Xu B, Han X, Mao Z, Chen M, Du G, Talbot P, Wang X, Xia Y*. The effects of triclosan on pluripotency factors and development of mouse embryonic stem cells and zebrafish. Arch Toxicol. 2015 Apr;89(4):635-46.IF=6.637

(10)Sharan A, Zhu H, Xie H, Li H, Tang J, Tang W, Zhang H, Xia Y*. Down-regulation of miR-206 is associated with Hirschsprung disease and suppresses cell migration and proliferation in cell models. Sci Rep. 2015 Mar 20;5:9302. IF=5.228

(11)Tang W, Tang J, He J, Zhou Z, Qin Y, Qin J, Li B, Xu X, Geng Q, Jiang W, Wu W, Wang X, Xia Y*. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. J Cell Mol Med. 2015 Jun;19(6):1197-207.IF=4.014

(12)Tang R, Chen M, Zhou K, Chen D, Yu J, Hu W, Song L, Hang B, Wang X, Xia Y*. Prenatal lignan exposures, pregnancy urine estrogen profiles and birth outcomes. Environ Pollut. 2015 Jun 18;205:261-268.IF=4.839

(13)Xu B, Ji X, Chen X, Yao M, Han X, Chen M, Tang W, Xia Y*. Effect of perfluorooctane sulfonate on pluripotency and differentiation factors in mouse embryoid bodies. Toxicology. 2015 Feb 3;328:160-7.IF=3.817

(14)Xu B, Chen M, Ji X, Mao Z, Zhang X, Wang X, Xia Y*. Metabolomic profiles delineate the potential role of glycine in gold nanorod-induced disruption of mitochondria and blood-testis barrier factors in TM-4 cells. Nanoscale. 2014 Jun 26;6(14):8265-73.IF=7.394

(15)Lu C, Jiang J, Zhang R, Wang Y, Xu M, Qin Y, Lin Y, Guo X, Ni B, Zhao Y, Diao N, Chen F, Shen H, Sha J, Xia Y*, Hu Z, Wang X. Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairment. Mol Hum Reprod. 2014 Sep;20(9):836-43.IF=3.747

(16)Qin Y, Du G, Chen M, Hu W, Lu C, Wu W, Hang B, Zhou Z, Wang X*, Xia Y*. Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility. Arch Toxicol. 2014 Aug;88(8):1527-36.IF=5.98

(17)Wang J, Xia Y(co-first), Wang G, Zhou T, Guo Y, Zhang C, An X, Sun Y, Guo X, Zhou Z, Sha J. In-depth proteomic analysis of whole testis tissue from the adult rhesus macaque. Proteomics. 2014 Jun;14(11):1393-402. IF=3.807

(18)Chen M, Zhou K, Chen X, Qiao S, Hu Y, Xu B, Xu B, Han X, Tang R, Mao Z, Dong C, Wu D, Wang Y, Wang S, Zhou Z, Xia Y*, Wang X. Metabolomic Analysis Reveals Metabolic Changes Caused By Bisphenol A in Rats. Toxicol Sci. 2014 Apr;138(2):256-67.IF=3.854

(19)Lu C, Xu M, Wang R, Qin Y, Wang Y, Wu W, Song L, Wang S, Shen H, Sha J, Miao D, Hu Z, Xia Y*, Wang X*. Pathogenic variants screening in five non-obstructive azoospermia associated genes. Mol Hum Reprod. 2014 Feb;20(2):178-83.IF=3.747

(20)Tang W, Li H, Tang J, Wu W, Qin J, Lei H, Cai P, Huo W, Li B, Rehan V, Xu X, Geng Q, Zhang H, Xia Y*. Specific serum microRNA profile in the molecular diagnosis of Hirschsprung's disease. J Cell Mol Med. 2014 Aug;18(8):1580-7.IF=4.014

(21)Xia Y*, Chen M, Zhu P, Lu C, Fu G, Zhou X, Chen D, Wang H, Hang B, Wang S, Zhou Z, Sha J, Wang X*. Urinary phytoestrogen levels related to idiopathic male infertility in Chinese men. Environ Int. 2013 Sep;59:161-7.IF=5.664

(22)Tang W, Qin J, Tang J, Zhang H, Zhou Z, Li B, Geng Q, Wu W, Xia Y*, Xu X*. Aberrant Reduction of MiR-141 Increased CD47/CUL3 in Hirschsprung's Disease. Cell Physiol Biochem. 2013 Dec 5;32(6):1655-67.IF=3.55

(23)Xu M, Qin Y, Qu J, Lu C*, Wang Y, Wu W, Song L, Wang S, Chen F, Shen H, Sha J, Hu Z, Xia Y*, Wang X*. Evaluation of Five Candidate Genes from GWAS for Association with Oligozoospermia in a Han Chinese Population. PLoS One. 2013 Nov 26;8(11):e80374.IF=3.534

(24)Wu W, Qin Y, Li Z, Dong J, Dai J, Lu C, Guo X, Zhao Y, Zhu Y, Zhang W, Hang B, Sha J, Shen H, Xia Y*, Hu Z, Wang X. Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p. Hum Reprod. 2013 Jul;28(7):1827-36.IF=4.585

(25)Lu C, Wang Y, Zhang F, Lu F, Xu M, Qin Y, Wu W, Li S, Song L, Yang S, Wu D, Jin L, Shen H, Sha J, Xia Y*, Hu Z, Wang X. DAZ duplications confer the predisposition of Y chromosome haplogroup K* to non-obstructive azoospermia in Han Chinese populations. Hum Reprod. 2013 Sep;28(9):2440-9.IF=4.585

(26)Chen M, Tang R, Fu G, Xu B, Zhu P, Qiao S, Chen X, Xu B, Qin Y, Lu C, Hang B, Xia Y*, Wang X. Association of exposure to phenols and idiopathic male infertility. J Hazard Mater. 2013, Feb 4;250-251C:115-121.IF=4.331

(27)Xu B, Chen X, Mao Z, Chen M, Han X, Du G, Ji X, Chang C, Rehan VK, Wang X, Xia Y*. Perfluorooctane Sulfonate Disturbs Nanog Expression through miR-490-3p in Mouse Embryonic Stem Cells. PLoS One. 2013 Oct 1;8(10):e74968.IF=3.534

(28)Qin Y, Chen M, Wu W, Xu B, Tang R, Chen X, Du G, Lu C, Meeker JD, Zhou Z, Xia Y*, Wang X*. Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility. PLoS One. 2013;8(3):e59398.IF=3.534

(29)Tang R, Chen MJ, Ding GD, Chen XJ, Han XM, Zhou K, Chen LM, Xia YK*, Tian Y*, Wang XR*. Associations of prenatal exposure to phenols with birth outcomes. Environ Pollut. 2013 Jul;178:115-20.IF=3.902

(30)Chen X, Chen M, Xu B, Tang R, Han X, Qin Y, Xu B, Hang B, Mao Z, Huo W, Xia Y*, Xu Z, Wang X. Parental phenols exposure and spontaneous abortion in Chinese population residing in the middle and lower reaches of the Yangtze River. Chemosphere. 2013 Sep;93(2):217-22.IF=3.499

(31)Chen X, Xu B, Han X, Mao Z, Talbot P, Chen M, Du G, Chen A, Liu J, Wang X, Xia Y*. Effect of bisphenol A on pluripotency of mouse embryonic stem cells and differentiation capacity in mouse embryoid bodies. Toxicol In Vitro.2013 Sep 30;27(8):2249-55. IF=3.207

(32)Tang W, Tang J, Qin J, Geng Q, Zhou Z, Li B, Zhang J, Chen H, Xia Y*, Wang X. Involvement of down-regulated E2F3 in Hirschsprung's disease. J Pediatr Surg. 2013 Apr;48(4):813-7.IF=1.311

(33)Tang W, Li B, Tang J, Liu K, Qin J, Wu W, Geng Q, Zhang J, Chen H, Xu X, Xia Y*. Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. Pediatr Surg Int. 2013 Jul;29(7):683-8.IF=1.061

(34)Shen H, Xu W, Zhang J, Chen M, Martin FL, Xia Y*, Liu L, Dong S, Zhu Y*. Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a Han Chinese population. Environ Sci Technol. 2013 Aug 6;47(15):8843-51.IF=5.481

(35)Hu Z, Xia Y(co-first author), Guo X, Dai J, Li H, Hu H, Jiang Y, Lu F, Wu Y, Yang X, Li H, Yao B, Lu C, Xiong C, Li Z, Gui Y, Liu J, Zhou Z, Shen H, Wang X, Sha J. A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet. 2012; 44(2):183-6.IF=35.532

(36)Wu W, Hu Z, Qin Y, Dong J, Dai J, Lu C, Zhang W, Shen H, Xia Y*, Wang X. Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol Hum Reprod. 2012 Oct;18(10):489-97.IF=4.542

(37)Han X, Tang R, Chen X, Xu B, Qin Y, Wu W, Hu Y, Xu B, Song L, Xia Y*, Wang X. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells. Toxicology. 2012 Dec 8;302(1):44-50.IF=4.017

(38)Qin Y, Han X, Peng Y, Shen R, Guo X, Cao L, Song L, Sha J, Xia Y*, Wang X*. Genetic variants in epoxide hydrolases modify the risk of oligozoospermia and asthenospermia in Han-Chinese population. Gene. 2012 Nov;36(9):608-15.IF=2.196

(39)Tang W, Li B, Xu X, Zhou Z, Wu W, Tang J, Qin J, Geng Q, Jiang W, Zhang J, Sha J, Xia Y*, Wang X. Aberrant high expression of NRG1 gene in Hirschsprung disease. J Pediatr Surg. 2012 Sep;47(9):1694-8.IF=1.383

(40)Chen M, Xu B, Ji W, Qiao S, Hu N, Hu Y, Wu W, Qiu L, Zhang R, Wang Y, Wang S, Zhou Z, Xia Y*, Wang X*. Bisphenol A Alters n-6 Fatty Acid Composition and Decreases Antioxidant Enzyme Levels in Rat Testes: A LC-QTOF-Based Metabolomics Study. PLoS One. 2012;7(9):e44754.IF=3.73

(41)Chen M, Zhu P, Xu B, Zhao R, Qiao S, Chen X, Tang R, Wu D, Song L, Wang S, Xia Y*, Wang X*. Determination of Nine Environmental Phenols in Urine by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry. J Anal Toxicol. 2012 Nov;36(9):608-15.IF=2.107

(42)Wen J, Jiang J, Ding C, Dai J, Liu Y, Xia Y*, Liu J*, Hu Z*. Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis. Fertil Steril. 2012 Jun;97(6):1331-7.e1-4.IF=4.174

(43)Hu W, Yang H, Sun J, Zhang Q, Yang J, Lu L, Zhang J, Qin Y, Xia Y*, Wang X*. Polymorphisms in CYP1B1 modify the risk of idiopathic male infertility with abnormal semen quality. Clin Chim Acta. 2011 Sep 18;412(19-20):1778-82.IF=2.535

 

5.  Scholarly and Professional Activities

Member, Academic Board, Birth Cohort Consortium of Asia (BiCCA)

Council Member, Chinese Society for Environmental Sciences

Standing Committee Member, Toxicity Testing Specialty Section, Chinese Environmental Mutagen Society

Committee Member of Toxicology, Chinese Preventive Medicine Association

Committee Member of Clinic Toxicology Specialty Section, Chinese Society of Toxicology

Committee Member of Reproductive Toxicology Specialty Section, Chinese Society of Toxicology